Surrogate end points in pulmonary arterial hypertension: Assessing the response to therapy

被引：36
|
作者：
Snow, Jennifer L.
Kawut, Steven M.
机构：
[1] Columbia Univ Coll Phys & Surg, Div Pulm Allergy & Crit Care Med, Dept Med, New York, NY 10032 USA
[2] Columbia Univ, Dept Epidemiol, Joseph L Mailman Sch Publ Hlth, New York, NY 10032 USA
[3] Univ Penn, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med, Philadelphia, PA 19104 USA
来源：
CLINICS IN CHEST MEDICINE | 2007年 / 28卷 / 01期
关键词：
D O I：
10.1016/j.ccm.2006.11.005
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Recent discoveries in the disease pathophysiology of pulmonary arterial hypertension have been translated into effective therapies tested in clinical trials. The studies have focused on surrogate and intermediate end points, thought to reflect quantity and quality of life, respectively The authors present the necessary requirements for establishing the reliability and validity of such end points before they may be used dependably. The authors also review the available data, strengths, and weaknesses of potential end points in pulmonary arterial hypertension.
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页码：75 / +
页数：16
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