Antifungal drug resistance

被引:168
|
作者
Loeffler, J
Stevens, DA
机构
[1] Santa Clara Valley Med Ctr, Dept Med, Div Infect Dis, San Jose, CA 94128 USA
[2] Univ Tubingen, Med Klin, Tubingen, Germany
[3] Stanford Univ, Sch Med, Stanford, CA 94305 USA
关键词
D O I
10.1086/344658
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term treatment or who are receiving antifungal prophylaxis, and there is growing awareness of shifts of flora to more-resistant species. The frequency, interpretation, and, in particular, mechanism of resistance to current classes of antifungal agents, particularly the azoles (where resistance has climbed most prominently) are discussed in this review.
引用
收藏
页码:S31 / S41
页数:11
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