Synthesis and bioactivity of aripiprazole derivatives

被引：0
|
作者：
Ge, Hai-Xia
Wang, Li-Chen [1 ]
Jiang, Zhen-Zhou
Ni, Sheng-Liang
机构：
[1] China Pharmaceut Univ, Dept Organ Chem, Nanjing 210009, Peoples R China
[2] Hu Zhou Teachers Coll, Huzhou, Peoples R China
[3] China Pharmaceut Univ, Xinzhong New Drug Res & Dev Ctr, Nanjing 210009, Peoples R China
来源：
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 2006年 / 56卷 / 10期
关键词：
antipsychotics; atypical; aripiprazole; derivatives; dopamine receptor antagonist activity; synthesis; CAS; 129722-12-9; dopamine receptor antagonists;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ten aripirazole (CAS 129722-12-9) derivatives were prepared and examined for dopamine receptor antagonist activity. The structures of these newly synthesized compounds were confirmed by their elemental analyses and by IR, H-1-NMR and mass spectra. It was demonstrated that all the new compounds have dopamine receptor antagonist activity to a certain extent. Three compounds showed more potent activity than aripiprazole.
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收藏
页码：673 / 677
页数：5
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