A new multicomponent domino transformation of 1,3-dicarbonyl compounds:: One-pot regio-, chemo- and stereoselective access to valuable α,γ-difunctionalized α-ketoesters and amides

被引：0
|
作者：
Habib-Zahmani, H
Hacini, S
Charonnet, E
Rodriguez, J
机构：
[1] Ctr St Jerome, CNRS, Lab ReSo React Synth Organ, UMR 6516, F-13397 Marseille 20, France
[2] Univ Oran Es Senia, Inst Chim, Organ Synth Lab, Oran 31000, Algeria
来源：
SYNLETT | 2002年 / 11期
关键词：
multi-component reaction; beta-ketoesters; beta-ketoamides; alpha; gamma-difunctionalization; azaspiro derivatives;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new multi-component transformation between 1,3-dicarbonyls 1, aldehydes 2, and allylic, propargylic or benzyfic halides 3 is described. It provides a regio-, chemo- and stereoselective one-pot access to alpha,-gamma-difunctionalized alpha-ketoesters and amides 4, bearing a quaternary center valuable for further synthetic transformations via ring-closing metathesis to give azaspiro systems found in bioactive natural products.
引用
收藏
页码：1827 / 1830
页数：4
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