c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination

被引：22
|
作者：
Ohrt, T
Mancini, A
Tamura, T
Niedenthal, R [1 ]
机构：
[1] Hannover Med Sch, Inst Biochem, D-30625 Hannover, Germany
[2] Tech Univ Dresden, Inst Biophys, D-01307 Dresden, Germany
来源：
CELLULAR SIGNALLING | 2004年 / 16卷 / 11期
关键词：
neurotrophin receptor p75; tyrosine phosphorylation; ubiquitination; signal transduction;
D O I：
10.1016/j.cellsig.2004.03.017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The p75 neurotrophin receptor (p75(NTR)) has dual functions in cell survival and cell death but its intracellular signalling pathways are not understood. Here we describe that in rat brain and in pervanadate-stimulated PCNA and HEK293 cells p75(NTR) is phosphorylated at a single tyrosine residue within the cytosolic C-terminus. Phosphorylated tyrosine 308 constitutes a binding site for the ubiquitin ligase c-Cbl. This interaction is a prerequisite for ubiquitination of p75(NTR). Our data suggest a c-Cbl-dependent ubiquitination of p75(NTR) involved in the regulation of p75 NTR signalling. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：1291 / 1298
页数：8
相关论文
共 50 条
  • [1] Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells
    Tsygankov, AY
    Mahajan, S
    Fincke, JE
    Bolen, JB
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (43) : 27130 - 27137
  • [2] THE PROTEIN PRODUCT OF THE C-CBL ONCOGENE RAPIDLY COMPLEXES WITH THE EGF RECEPTOR AND IS TYROSINE-PHOSPHORYLATED FOLLOWING EGF STIMULATION
    BOWTELL, DDL
    LANGDON, WY
    ONCOGENE, 1995, 11 (08) : 1561 - 1567
  • [3] Role of tyrosine phosphorylation in the antioxidant effects of the p75 neurotrophin receptor
    Zhang, Tong
    Mi, Zhiping
    Schor, Nina F.
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2009, 2 (04) : 238 - 246
  • [4] The neurotrophin receptor p75 binds neurotrophins on sympathetic neurons with high affinity and specificity
    Dechant, G
    Tsoulfas, P
    Parada, LF
    Barde, YA
    JOURNAL OF NEUROSCIENCE, 1997, 17 (14): : 5281 - 5287
  • [5] c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts
    Odai, H
    Sasaki, K
    Hanazono, Y
    Ueno, H
    Tanaka, T
    Miyagawa, K
    Mitani, K
    Yazaki, Y
    Hirai, H
    JAPANESE JOURNAL OF CANCER RESEARCH, 1995, 86 (12): : 1119 - 1126
  • [6] p75 Neurotrophin Receptor in the Skin: Beyond Its Neurotrophic Function
    Pincelli, Carlo
    FRONTIERS IN MEDICINE, 2017, 4
  • [7] The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor
    Saadipour, Khalil
    MacLean, Michael
    Pirkle, Sean
    Ali, Solav
    Lopez-Redondo, Maria-Luisa
    Stokes, David L.
    Chao, Moses V.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (40) : 16594 - 16604
  • [8] Beta amyloid binds the p75 neurotrophin receptor: implications for aging and Alzheimer's disease
    Yaar, M
    Gilchrest, BA
    MOLECULAR BIOLOGY OF AGING, 1999, 44 : 159 - 170
  • [9] c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages
    Wang, Y
    Yeung, YG
    Langdon, WY
    Stanley, ER
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (01) : 17 - 20
  • [10] Osmotic swelling induces p75 neurotrophin receptor (p75NTR) expression via nitric oxide
    Peterson, S
    Bogenmann, E
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) : 33943 - 33950
12345