Effects of glucocorticoids on polyamine metabolism in liver and spleen of guinea pig during sensitization

被引：6
|
作者：
Bjelakovic, G. [1 ]
Pavlovic, D. [1 ]
Stojanovic, I. [1 ]
Jevtovic, T. [1 ]
Nikolic, J. [1 ]
Kocic, G. [1 ]
机构：
[1] Univ Nis, Fac Med, Inst Biochem, Nish 18000, Serbia
来源：
AMINO ACIDS | 2006年 / 31卷 / 04期
关键词：
polyamines; polyamine oxidase; dexamethasone; sensitization; liver; spleen; guinea pigs;
D O I：
10.1007/s00726-005-0286-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glucocorticoids are potent anti-inflammatory and immunosuppressive agents. As endogenous inhibitors of cytokine synthesis, glucocorticoids suppress immune activation and uncontrolled overproduction of cytokines, preventing tissue injury. Also, polyamine spermine is endogenous inhibitor of cytokine production (inhibiting IL-1, IL-6 and TNF synthesis). The idea of our work was to examine dexamethasone effects on the metabolism of polyamines, spermine, spermidine and putrescine and polyamine oxidase activity in liver and spleen during sensitization of guinea pigs. Sensitization was done by application of bovine serum albumin with addition of complete Freund's adjuvant. Our results indicate that polyamine amounts and polyamine oxidase activity increase during immunogenesis in liver and spleen. Dexamethasone application to sensitized and unsensitized guinea pigs causes depletion of polyamines in liver and spleen. Dexamethasone decreases polyamine oxidase activity in liver and spleen of sensitized guinea pigs, increasing at the same time PAO activity in tissues of unsensitized animals.
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页码：457 / 462
页数：6
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