New Vaccine Design and Delivery Technologies

被引：45
|
作者：
Kanekiyo, Masaru [1 ]
Ellis, Daniel [2 ,3 ]
King, Neil P. [2 ,4 ]
机构：
[1] NIAID, Vaccine Res Ctr, NIH, 40 Convent Dr, Bethesda, MD 20892 USA
[2] Univ Washington, Inst Prot Design, Seattle, WA 98195 USA
[3] Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA
[4] Univ Washington, Dept Biochem, Seattle, WA 98195 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷
基金：
美国国家卫生研究院;
关键词：
universal influenza vaccine; antigen design; structure-based vaccine; protein engineering; nanoparticle; antigen display; mRNA vaccine; broadly neutralizing antibody; INFLUENZA-VIRUS HEMAGGLUTININ; GLOBULAR HEAD; BINDING; PROTEIN; LIVE; IMMUNOGENICITY; STABILIZATION; ATTENUATION; ANTIBODIES; STRATEGY;
D O I：
10.1093/infdis/jiy745
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Technological advances in immunology, protein design, and genetic delivery have unlocked new possibilities for vaccine concepts and delivery technologies that were previously inaccessible. These next-generation vaccine design efforts are particularly promising in their potential to provide solutions to challenging targets for which conventional approaches have proven ineffective-for example, a universal influenza vaccine. In this perspective, we discuss emerging approaches to vaccine design and engineering based on recent insights into immunology, structural biology, computational biology, and immunoengineering. We anticipate that these cutting-edge, interdisciplinary approaches will lead to breakthrough vaccine concepts for ever-evolving and (re) emerging influenza viruses, with important ramifications for global public health.
引用
收藏
页码：S88 / S96
页数：9
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