p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population

被引：11
|
作者：
Ye, Feng [1 ,2 ]
Zhang, Jing [2 ]
Cheng, Qi [1 ]
Shen, Jiajie [1 ]
Chen, Huaizeng [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Womens Hosp, Womens Reprod Hlth Lab Zhejiang Prov, Hangzhou 310006, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Womens Hosp, Dept Gynecol Oncol, Hangzhou 310006, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2010年 / 287卷 / 01期
关键词：
Single nucleotide polymorphism; Cervical carcinoma; p53; Cation; 72; proline; SQUAMOUS INTRAEPITHELIAL LESIONS; HUMAN-PAPILLOMAVIRUS; CANCER; RISK; GENOTYPES;
D O I：
10.1016/j.canlet.2009.06.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the genotype distribution of the p53 Arg72Pro polymorphisms in 500 cervical carcinoma and 800 normal women in Chinese population. HPV infection rates in carcinoma patients and control were 89.4% and 31.0%. Women carrying the p53 Arg72Pro or p53 Pro72Pro increased the risk of cervical carcinoma (ORs and 95% CIs being 3.74 (2.65-5.30), 2.23 (1.49-3.34)). In HPV positive population, elevated risks were also associated with p53 Arg72Pro, Pro72Pro (ORs and 95% CIs being 3.83 (2.02-7.24), 2.38 (1.14-4.99)). These results suggest that a proline in position 72 of p53 increases the risk of cervical carcinoma in Chinese population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：117 / 121
页数：5
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