Slow delayed rectifier potassium current (IKs) and the repolarization reserve

被引：67
|
作者：
Jost, Norbert
Papp, Julius Gy.
Varró, Andras
机构：
[1] Univ Szeged, Dept Pharmacol & Pharmacotherapy, Fac Med, Albert Szent Gyorgyi Med Ctr, H-6701 Szeged, Hungary
[2] Hungarian Acad Sci, Div Cardiovasc Pharmacol, Szeged, Hungary
来源：
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY | 2007年 / 12卷 / 01期
关键词：
K+ current; I-Ks; cardiac action potential; repolarization reserve; arrhythmias; long-QT syndrome;
D O I：
10.1111/j.1542-474X.2007.00140.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this review is to present the properties of the slow component of the delayed rectifier potassium current (I-Ks) in the human ventricle. The review gives a detailed description of the physiology, molecular biology and pharmacology of the I-Ks current, including kinetic properties, genetic structures, agonists and antagonists. The authors also present the role of the I-Ks current in the human cardiac repolarization focusing on several pathophysiological situations, such as the LQT syndrome and the Torsade de Pointes arrhythmia.
引用
收藏
页码：64 / 78
页数：15
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