Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages

被引:21
|
作者
Dasari, Rajaneekar [1 ]
Bonsack, Frederick [1 ]
Sukumari-Ramesh, Sangeetha [1 ]
机构
[1] Augusta Univ, Med Coll Georgia, Dept Pharmacol & Toxicol, 1120 15th St,CB3618, Augusta, GA 30912 USA
基金
美国国家卫生研究院;
关键词
Intracerebral hemorrhage; Microglia; Macrophages; Brain injury; Repair; ACUTE INFLAMMATORY REACTION; FACTOR-KAPPA-B; CELL-DEATH; RECEPTOR; 4; MICROGLIA/MACROPHAGE POLARIZATION; NEUROLOGICAL DEFICITS; HEMATOMA RESOLUTION; ACTIVATED MICROGLIA; SIGNALING PATHWAY; HEME OXYGENASE;
D O I
10.1016/j.neuint.2020.104923
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intracerebral hemorrhage (ICH) is a major public health problem characterized by cerebral bleeding. Despite recent advances in preclinical studies, there is no effective treatment for ICH making it the deadliest subtype of stroke. The lack of effective treatment options partly attributes to the complexity as well as poorly defined pathophysiology of ICH. The emerging evidence indicates the potential of targeting secondary brain damage and hematoma resolution for improving neurological outcomes after ICH. Herein, we provide an overview of our understanding of the functional roles of activated microglia and brain-infiltrating monocyte-derived macrophages in brain injury and repair after ICH. The clinical and preclinical aspects that we discuss in this manuscript are related to ICH that occurs in adults, but not in infants. Also, we attempt to identify the knowledge gap in the field for future functional studies given the potential of targeting microglia and brain-infiltrating macrophages for therapeutic intervention after ICH.
引用
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页数:8
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