Identification of a basal-like subtype of breast ductal carcinoma in situ

被引:169
|
作者
Livasy, Chad A. [1 ]
Perou, Charles M.
Karaca, Gamze
Cowan, David W.
Maia, Diane
Jackson, Susan
Tse, Chiu-Kit
Nyante, Sarah
Millikan, Robert C.
机构
[1] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
关键词
basal-like subtype; ductal carcinoma in situ; estrogen receptor-negative; breast carcinoma;
D O I
10.1016/j.humpath.2006.08.017
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Microarray profiling of invasive breast carcinomas has identified subtypes including luminal A, luminal B, HER2-overexpressing, and basal-like. The poor-prognosis, basal-like tumors have been immunohistochemically characterized as estrogen receptor (ER)-negative, HER2/neu negative, and cytokeratin 5/6-positive and/or epidermal growth factor receptor (EGFR)-positive. The aim of this study was to determine the prevalence of basal-like ductal carcinoma in situ in a population-based series of cases using immunohistochemical surrogates. A total of 245 pure ductal carcinoma in situ cases from a population-based, case-control study were evaluated for histologic characteristics and immunostained for ER, HER2/neu, EGFR, cytokeratin 5/6, p53, and Ki-67. The subtypes were defined as: luminal A (ER+, HER2-), luminal B (ER+, HER2+), HER2, positive (ER-, HER2+), and basal-like (ER-, HER2-, EGFR+, and/or cytokeratin 5/6+). The prevalence of breast cancer subtypes was basal-like (n = 19 [8%]); luminal A, n = 149 (61%); luminal B, n = 23 (9%); and HER2+/ER-, n = 38 (16%). Sixteen tumors (6%) were unclassified (negative for all 4 defining markers). The basal-like subtype was associated with unfavorable prognostic variables including high-grade nuclei (P < .0001), p53 overexpression (P < .0001), and elevated Ki-67 index (P < .0001). These studies demonstrate the presence of a basal-like in situ carcinoma, a potential precursor lesion to invasive basal-like carcinoma. (c) 2007 Elsevier Inc. All rights reserved.
引用
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页码:197 / 204
页数:8
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