Association of NLRP1 (rs878329) and NLRP3 (rs10754558) genes polymorphism in psoriasis vulgaris patients with dyslipidemia

Introduction and aim: NLRP inflammasome is intracellular sensors and not yet fully studied in psoriasis vulgaris. The aim was to investigate the association of NLRP1 (rs878329) and NLRP3 (rs10754558) genes polymorphism and psoriasis vulgaris, and their relations with the clinical and lipid profiles in psoriatic patients. Material and methods: This study was involved 64 patients with psoriasis vulgaris and 64 healthy control group. Blood sample was taken for lipid profiles and genotypes NLRP1 and NLRP3 using single-nucleotide polymorphism (SNP) assay. Results: Total cholesterol and LDL-c were significantly increased in psoriatic patients compared to controls and their significantly correlation with PASI score (r = 0.296, 0.309 respectively; P < 0.05). On analyzing NLRP1 genotypes CG and GG; and the allele G showed significantly higher frequency in psoriatic patients with 4, 9 and 3 times increase in the risk of developing psoriasis vulgaris respectively; and was significantly associated with dyslipidemia. While on analyzing NLRP3 genotypes GC and CC; and the allele C showed significantly higher frequency in psoriatic patients with 6, 9 and 3 times increase in the risk of developing psoriasis vulgaris respectively. The genotype CC was significantly associated with family history of psoriasis (46.7%), site of affection distribution in extremities and axial (P = 0.015), and with severe form of psoriasis (40.0%) than genotypes GG and GC. However, NLRP3 genotypes was non-significantly associated with dyslipidemia. Conclusions: NLRP1 and NLRP3 genotypes polymorphism associated with more susceptibility to psoriasis vulgaris associated with dyslipidemia. NLRP3 genotypes polymorphism could assess severity and a pivotal therapeutic target in psoriasis vulgaris pathogenesis.