Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes

被引：0
|
作者：
Post, SM [1 ]
deWit, ECM [1 ]
Princen, HMG [1 ]
机构：
[1] TNO,GAUBIUS LAB,PG,LEIDEN,NETHERLANDS
来源：
ATHEROSCLEROSIS | 1997年 / 134卷 / 1-2期
关键词：
D O I：
10.1016/S0021-9150(97)89705-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：333 / 333
页数：1
相关论文
共 50 条
  • [1] Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes
    Post, SM
    deWit, ECM
    Princen, HMG
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) : 3064 - 3070
  • [2] INSULIN SUPPRESSES BILE-ACID SYNTHESIS IN CULTURED RAT HEPATOCYTES BY DOWN-REGULATION OF CHOLESTEROL 7-ALPHA-HYDROXYLASE AND STEROL 27-HYDROXYLASE GENE-TRANSCRIPTION
    TWISK, J
    HOEKMAN, MFM
    LEHMANN, EM
    MEIJER, P
    MAGER, WH
    PRINCEN, HMG
    HEPATOLOGY, 1995, 21 (02) : 501 - 510
  • [3] Fibrates suppress bile acid synthesis via PPARα-mediated down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene expression
    Post, SM
    Staels, B
    de Fabiani, E
    Chiang, JYL
    Princen, HMG
    Crestani, M
    ATHEROSCLEROSIS, 1999, 144 : 23 - 23
  • [4] Hepatic bile acid pool regulates cholesterol 7 alpha-hydroxylase but not sterol 27-hydroxylase in cholesterol fed New Zealand white rabbits
    Xu, G
    Salen, G
    Nguyen, LB
    Tint, GS
    Shefer, S
    HEPATOLOGY, 1996, 24 (04) : 732 - 732
  • [5] Nuclear receptor regulation of the human cholesterol 7α-hydroxylase, sterol 27-hydroxylase and sterol 12α-hydroxylase genes in bile acid synthesis
    Chiang, JYL
    Chen, W
    Zhang, M
    Cowsley, E
    Yang, YZ
    BIOLOGY OF BILE ACIDS IN HEALTH AND DISEASE, 2001, 120 : 17 - 25
  • [6] REGULATION OF BILE-ACID SYNTHESIS BY DEOXYCHOLIC-ACID IN THE RAT - DIFFERENT EFFECTS ON CHOLESTEROL 7-ALPHA-HYDROXYLASE AND STEROL 27-HYDROXYLASE
    SHEFER, S
    KREN, BT
    SALEN, G
    STEER, CJ
    NGUYEN, LB
    CHEN, T
    TINT, GS
    BATTA, AK
    HEPATOLOGY, 1995, 22 (04) : 1215 - 1221
  • [7] Comparative regulation of sterol 27-hydroxylase and cholesterol 7α-hydroxylase activities:: Effects of cholesterol and bile acids.
    Nguyen, LB
    Shefer, S
    Xu, G
    Salen, G
    Tint, GS
    Batta, AK
    HEPATOLOGY, 1998, 28 (04) : 378A - 378A
  • [8] Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes
    Post, SM
    Twisk, J
    van der Fits, L
    de Wit, ECM
    Hoekman, MFM
    Mager, WH
    Princen, HMG
    BIOCHEMICAL JOURNAL, 1999, 341 : 339 - 346
  • [9] Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes
    Post, Sabine M.
    Twisk, Jaap
    van der Fits, Leslie
    de Wit, Elly C.M.
    Hoekman, Marco F.M.
    Mager, Willem H.
    Princen, Hans M.G.
    Biochemical Journal, 341 (02): : 339 - 346
  • [10] STRUCTURAL ASPECTS OF BILE-ACIDS INVOLVED IN THE REGULATION OF CHOLESTEROL 7-ALPHA-HYDROXYLASE AND STEROL 27-HYDROXYLASE
    TWISK, J
    HOEKMAN, MFM
    MULLER, LM
    IIDA, T
    TAMARU, T
    IJZERMAN, A
    MAGER, WH
    PRINCEN, HMG
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 228 (03): : 596 - 604
12345