Does sucralfate reduce early side effects of pelvic radiation? A double-blind randomized trial

被引：15

作者：

Stellamans, K

Lievens, Y

Lambin, P

Van den Weyngaert, D

Van den Bogaert, W

Scalliet, P

Hutsebaut, L

Haustermans, K

机构：

[1] UZ Gasthuisberg, Univ Hosp Leuven, Dept Radiotherapy, B-3000 Louvain, Belgium

[2] AZ Middelheim, Dept Radiotherapy, Antwerp, Belgium

[3] UZ Gasthuisberg, Dept Pharmaceut, Louvain, Belgium

来源：

RADIOTHERAPY AND ONCOLOGY | 2002年 / 65卷 / 02期

关键词：

sucralfate; pelvic irradiation; side effects;

D O I：

10.1016/S0167-8140(02)00281-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Study and methods: A double-blind placebo-controlled study randomized 108 patients to investigate the effect of sucralfate on gastrointestinal side effects of pelvic radiation. Results: Overall, pelvic radiation with the administered doses and fields and performed according to nowadays technical standards, was well tolerated. Comparison of the mean scores and the peak reactions for radiotherapy discomfort, diarrhoea and number of stools per day in the 80 evaluable patients showed no statistically significant difference between sucralfate and placebo. Conclusion: Based on these results, the use of sucralfate can not be recommended as standard practice. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 108

页数：4

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