Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population

被引：39
|
作者：
Hang, Dong [1 ]
Yin, Yin [1 ]
Han, Jing [1 ]
Jiang, Jie [1 ]
Ma, Hongxqia [1 ]
Xie, Shuanghua [2 ]
Feng, Xiaoshuang [2 ]
Zhang, Kai [3 ]
Hu, Zhibin [1 ,4 ]
Shen, Hongbing [1 ,4 ]
Clifford, Gary M. [5 ]
Dai, Min [2 ]
Li, Ni [2 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Jiangsu, Peoples R China
[2] Chinese Acad Med Sci, Canc Inst & Hosp, Natl Off Canc Prevent & Control, 17 Panjiayuannanli, Beijing 100021, Peoples R China
[3] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Canc Prevent, Beijing 100021, Peoples R China
[4] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China
[5] Int Agcy Res Canc, Infect & Canc Epidemiol, F-69372 Lyon, France
来源：
VIROLOGY | 2016年 / 488卷
基金：
中国国家自然科学基金; 中国博士后科学基金; 北京市自然科学基金;
关键词：
Human papillomavirus 16; Variant; Cervical cancer; Case-control study; Meta-analysis; NATURAL VARIANTS; INTRAEPITHELIAL NEOPLASIA; TYPE-16; E6; HUMAN-PAPILLOMAVIRUS-16; WORLDWIDE; WOMEN; GENE; KERATINOCYTES; METAANALYSIS;
D O I：
10.1016/j.virol.2015.11.016
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：156 / 161
页数：6
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