ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia

被引：1
|
作者：
Srisuttayasathien, Manasawee [1 ,2 ]
Areepium, Nutthada [3 ]
Lertkhachonsuk, Ruangsak [1 ,2 ]
机构：
[1] Chulalongkorn Univ, Fac Med, Div Gynecol Oncol, Dept Obstet & Gynecol, Bangkok 10330, Thailand
[2] King Chulalongkorn Mem Hosp, Bangkok 10330, Thailand
[3] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharm Practice, Bangkok 10330, Thailand
来源：
PERSONALIZED MEDICINE | 2021年 / 18卷 / 02期
关键词：
ABCB1; polymorphism; biomarker; chemotherapy response; Low-risk gestational trophoblastic neoplasia; methotrexate; personalized treatment; post-molar gestational trophoblastic neoplasia; predicting methotrexate resistant; single nucleotide polymorphism;
D O I：
10.2217/pme-2020-0089
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The aim of this study was to explore the effects of ABCB1 and SLCO1B1 gene polymorphisms and the methotrexate (MTX) treatment response in patients with low-risk gestational trophoblastic neoplasia (GTN). Materials & methods: Low-risk GTN patients who received MTX as a first-line single agent were enrolled. DNA was extracted from peripheral blood samples from 18 patients and assessed for ABCB1 C3435T and SLCO1B1 T521C. Results: ABCB1 C3435T and SLCO1B1 T521C polymorphisms were not associated with the MTX response or toxicity in Thai patients Conclusion: The selected ABCB1 and SLCO1B1 polymorphism do not predict the risk of MTX resistance in low-risk GTN.
引用
收藏
页码：107 / 114
页数：8
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