Effect of mifepristone combined with interventional embolization on patients with uterine fibroids

Objective: To investigate the effect of mifepristone combined with interventional embolization on uterine blood supply and menstruation in patients with uterine fibroids. Methods: Ninety patients with uterine fibroids in The Second Peopleith uterine fibDongying were divided into a control group and an observation group according to the order of treatment, with 45 cases in each group. The control group received interventional embolization of the uterine artery, whereas the observation group received treatment with mifepristone plus the surgical procedure. Changes in uterine volume, uterine fibroid volume, uterine fibroid blood supply, menstrual blood volume, menstrual period and ovarian hormones were recorded before and after treatment in both groups, and the prognosis was statistically analyzed. Results: Compared with before treatment, both groups had reduced uterine volume and uterine fibroid volume after treatment, but the uterine volume and uterine fibroid volume were significantly smaller in the observation group than in the control group during the same period (all P < 0.05). The average flow rate, peak systolic velocity and thickest artery diameter of both groups were lower after surgery than before treatment, while the resistance index was higher than before treatment. The improvement degree of the observation group was significantly higher than that of the control group (all P < 0.05). The levels of progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone in the observation group were significantly lower after treatment, and these levels were significantly lower in the observation group than in the control group during the same period (all P < 0.05). After 6 months of treatment, the number of menstrual period and menstrual blood volume were significantly reduced in both groups, but the menstrual period and menstrual blood volume were significantly lower in the observation group than in the control group (all P < 0.05). The required time for postoperative menstrual recovery to normal level of the observation group was also significantly longer than that of the control group (P < 0.001). Postoperative complications were significantly less frequent in the observation group than in the control group (P = 0.036). Conclusion: In patients with uterine fibroids, mifepristone combined with interventional embolization can effectively reduce uterine blood supply, restore ovarian function, and reduce postoperative complications, which is worthy of clinical application and promotion.