Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1

被引：10
|
作者：
Martinez-Fleites, Carlos [1 ]
Smith, Nicola L. [2 ,3 ]
Turkenburg, Johan P. [1 ]
Black, Gary W. [2 ]
Taylor, Edward J. [1 ]
机构：
[1] Univ York, Dept Chem, Struct Biol Lab, York YO10 5DD, N Yorkshire, England
[2] Northumbria Univ, Sch Appl Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England
[3] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS | 2009年 / 65卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
MODEL;
D O I：
10.1107/S1744309109032813
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The crystal structures of truncated forms of the Streptococcus pyogenes phage-encoded hyaluronate lyases HylP2 and HylP3 were determined by molecular replacement to 1.6 and 1.9 angstrom resolution, respectively. The truncated forms crystallized in a hexagonal space group, forming a trimer around the threefold crystallographic axis. The arrangement of the fold is very similar to that observed in the structure of the related hyaluronate lyase HylP1. The structural elements putatively involved in substrate recognition are found to be conserved in both the HylP2 and HylP3 fragments.
引用
收藏
页码：963 / 966
页数：4
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