Indocarbazostatins C and D, new inhibitors of NGF-induced neuronal differentiation in PC12 cells

被引：9
|
作者：
Feng, YF
Matsuura, N
Ubukata, M
机构：
[1] Hokkaido Univ, Grad Sch Agr, Kita Ku, Sapporo, Hokkaido 0608589, Japan
[2] Okayama Univ Sci, Fac Sci, Dept Life Sci, Okayama 7000005, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 10期
关键词：
D O I：
10.7164/antibiotics.57.627
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Indocarbazostatins C (3) and D (4), new inhibitors of NGF-induced neurite outgrowth were isolated from culture broth of a mutant strain, Streptomyces sp. MUV-6-83. The structural elucidation of 3 and 4 revealed that these inhibitors were methyl ester analogs of the corresponding ethyl ester compounds, indocarbazostatin (1) and indocarbazostatin B (2), respectively.
引用
收藏
页码：627 / 633
页数：7
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