Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study

被引：2

作者：

Li Hai-Xia ^{[1
]}

Liu Yan-Cheng ^{[2
]}

Tang Rui-Zhi ^{[2
]}

Zhang Peng ^{[2
]}

Ma Liu-Kui ^{[1
]}

Wei Chi-Yuan ^{[1
]}

Wang Wen-Feng ^{[2
]}

机构：

[1] Nanjing Tech Univ, Pujiang Inst, Nanjing 211132, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

来源：

ACTA PHYSICO-CHIMICA SINICA | 2017年 / 33卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Laser flash photolysis; Difloxacin; Triplet state; Amino acid; AQUEOUS-SOLUTION; PULSE-RADIOLYSIS; PROTEINS; RADICALS; DNA; OXIDATION; TOXICITY; CHEMISTRY; REPAIR; OXYGEN;

D O I：

10.3866/PKU.WHXB201702201

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The reactions of triplet-state difloxacin (DFX) with various amino acids and deoxyguanylic acid in aqueous media were studied using laser flash photolysis. Tryptophan, tyrosine, cysteine, and 2'-deoxyguanosine5'-monophosphate (dGMP) were found to completely quench the triplet state of DFX in aqueous solution, the corresponding second-order rate constants being 1.97 x 10(8), 1.48 x 10(8), 1.72 x 10(8), and 6.92 x 10(7) dm(3).mol(-l).s(-1) . The quenching mechanism involves electron transfer to the photoexcited triplet state of DFX from the tryptophan, tyrosine, cysteine, and dGMP moieties, followed by fast protonation of the resulting DFX anion radical.

引用

页码：1051 / 1056

页数：6

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