Venous Thromboembolism in Sickle Cell Disease is Associated with Neutrophilia

被引：8

作者：

Gollamudi, Jahnavi ^{[1
]}

Sarvepalli, Shashank ^{[2
]}

Vadaparti Binf, Animesh ^{[3
]}

Alin, Tara ^{[4
,5
]}

Little, Jane A. ^{[4
,5
]}

Nayak, Lalitha ^{[6
]}

机构：

[1] Baylor Coll Med, Dept Internal Med, Div Hematol Oncol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Internal Med, Div Gastroenterol, Houston, TX 77030 USA

[3] Guelph Univ, Dept Integrat Biol, Guelph, ON, Canada

[4] Univ N Carolina, Div Hematol, Chapel Hill, NC 27515 USA

[5] Univ N Carolina, UNC Blood Res Ctr, Dept Internal Med, Chapel Hill, NC 27515 USA

[6] Seidman Canc Ctr, Dept Internal Med, Div Hematol Oncol, Cleveland, OH USA

来源：

HEMOGLOBIN | 2021年 / 45卷 / 01期

关键词：

Leukocytosis; neutrophilia; predictors; sickle cell disease; venous thromboembolism (VTE);

D O I：

10.1080/03630269.2020.1869565

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Venous thromboembolism (VTE) in individuals with sickle cell disease is common and portends a poor prognosis. The role of leukocyte count and its subsets on risk of VTE in sickle cell disease are not known. We conducted a retrospective case-control study and analyzed for leukocyte count at the time of VTE and 3 months prior. Leukocyte and neutrophil counts were elevated at the time of VTE (p = 0.003 and p = 0.0006, respectively) and 3 months prior (p = 0.001 and p = 0.0096, respectively) when compared to controls. Baseline leukocytosis and neutrophilia may be associated with subsequent risk for thrombosis in sickle cell disease.

引用

页码：56 / 59

页数：4

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