An operator T is an element of L(H) is said to be (m, C)-isometric if there exists a conjugation C such that Sigma(m)(j=0) (-1)(m-j) ((m)(j))T*(CTC)-C-j-C-j = 0 for some positive integer m. In this paper, we study (m, C)-isometric Toeplitz operators T-phi with rational symbols phi. We characterize (m, C)-isometric Toeplitz operators T-phi by properties of the rational symbols phi. Moreover, we provide a concrete description of the (m, C)-isometric block Toeplitz operators.