Altered GABAA Receptor Expression as Biomarker of Mercury Toxicity in Embryonic Neurogenesis

被引：0
|
作者：
Ayensu, Wellington K. [1 ]
Isokpehi, Raphael D. [1 ]
Cohly, Hari H. [1 ]
Murray, Jessica M. [2 ]
Webb, Demareo J. [1 ]
Tchounwou, Paul B. [3 ]
机构：
[1] Jackson State Univ, Dept Biol, Ctr Bioinformat & Computat Biol, Jackson, MS 39217 USA
[2] St Louis Univ, St Louis, MO 63103 USA
[3] Jackson State Univ, CSET, Coll Sci Engn & Technol, NIH Ctr Environm Hlth ,Mol Toxicol Res Lab, Mississippi State, MS USA
来源：
2009 FIRST ANNUAL ORNL BIOMEDICAL SCIENCE & ENGINEERING CONFERENCE: EXPLORING THE INTERSECTIONS OF INTERDISCIPLINARY BIOMEDICAL RESEARCH | 2009年
基金：
美国国家卫生研究院;
关键词：
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Mouse brain microarray dataset (GDS2702) on embryonic days 14.5 (E14.5), 16.5 (E16.5 and 18.5 (E18.5) was investigated for gene expression patterns of GABA receptors. Gabbr1, Gabra2, Gabrb3 and Gabrg2 were the only four GABA receptor genes expressed at stage E14.5 and E16.5. However, at stage E18.5, four additional genes (Gabra1, Gabra3, Gabrg1 and Gabrg3) were expressed. Gabbr1 had the highest intensity in all the three embryonic days. Gabra6, Gabrb2, Gabrd, Gabrr1 and Gabrr2 were not expressed in all the 3 samples analyzed. It is proposed that Gabra6 receptor is a potential biomarker for neuronal toxicity that can arise from maternal exposures to low doses of mercury through diet, water and air pollutions.
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页码：136 / +
页数：2
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