Immunologic Markers as Predictors of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in HIV and Tuberculosis Coinfected Persons in Thailand

被引：32
|
作者：
Van Tieu, Hong [1 ]
Ananworanich, Jintanat [2 ,3 ]
Avihingsanon, Anchalee [2 ,4 ]
Apateerapong, Wichitra [3 ]
Sirivichayakul, Sunee [4 ,5 ]
Siangphoe, Umaporn [3 ]
Klongugkara, Sukonsri [6 ]
Boonchokchai, Benjawan [3 ]
Hammer, Scott M.
Manosuthi, Weerawat [6 ]
机构：
[1] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA
[2] HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand
[3] SE Asia Res Collaborat Hawaii, Bangkok, Thailand
[4] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand
[5] Chulalongkorn Univ, Bangkok, Thailand
[6] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2009年 / 25卷 / 11期
关键词：
ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; RESTORATION DISEASE; RISK-FACTORS; INITIATION; RESPONSES; TYPE-1;
D O I：
10.1089/aid.2009.0055
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study analyzes immunologic markers to predict and diagnose tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in HIV and TB coinfected adults who initiated antiretroviral therapy (ART) in Thailand. T helper 1 cytokines interleukin (IL)-2, IL-12, and interferon-gamma (IFN-gamma) levels in response to PPD and RD1 antigens were assessed prior to ART, at weeks 6, 12, and 24 of treatment, and at time of TB-IRIS. Of 126 subjects, 22 (17.5%) developed TB-IRIS; 14 (64%) subjects received steroid treatment and 3 (14%) received NSAIDs; none of the subjects died. Median interval between ART initiation and TB-IRIS development was 14 days. IFN-gamma, IL-2, and IL-12 responses did not differ between TB-IRIS and no TB-IRIS subjects (p>0.05). More research into the immunopathogenesis of TB-IRIS and diagnostic potential of cytokine markers is warranted.
引用
收藏
页码：1083 / 1089
页数：7
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