Plasmodium falciparum cGMP-Dependent Protein Kinase - A Novel Chemotherapeutic Target

被引：12
|
作者：
Rotella, David [1 ]
Siekierka, John [1 ]
Bhanot, Purnima [2 ]
机构：
[1] Montclair State Univ, Dept Chem & Biochem, Montclair, NJ USA
[2] Rutgers New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ 07103 USA
来源：
FRONTIERS IN MICROBIOLOGY | 2021年 / 11卷
基金：
美国国家卫生研究院;
关键词：
Plasmodium; malaria; cGMP signaling; second messenger; kinase;
D O I：
10.3389/fmicb.2020.610408
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting against malaria. PfPKG is essential in the asexual erythrocytic and sexual cycles as well as the pre-erythrocytic cycle. Medicinal chemistry efforts, both target-based and phenotype-based, have targeted PfPKG in the past few years. This review provides a brief overview of their results and challenges.
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页数：7
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