The Gut-Liver Axis in Primary Sclerosing Cholangitis

被引：38
|
作者：
Eksteen, Bertus [1 ]
机构：
[1] Univ Calgary, Snyder Inst Chron Dis, Hlth Res & Innovat Ctr, Div Gastroenterol & Hepatol, Calgary, AB T2N 4N1, Canada
来源：
CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 01期
关键词：
Primary sclerosing cholangitis; Inflammatory bowel disease; Vedolizumab; Cholangiocarcinoma; Genetics; Microbiome; Pouchitis; INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; POUCH-ANAL ANASTOMOSIS; ULCERATIVE-COLITIS; URSODEOXYCHOLIC ACID; CROHNS-DISEASE; RISK LOCI; T-CELLS; MAINTENANCE THERAPY; CONTROLLED-TRIAL;
D O I：
10.1016/j.cld.2015.08.012
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Dysregulation of the ke genetic, immunologic, and microbiome compounds of the gut-liver axis is the basis for inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC). This creates opportunities to accelerate therapies that have been traditionally developed for IBD to be used in PSC to the benefit of both diseases. Shared genetic susceptibility loci has yielded important clues into the pathogenesis of PSC-IBD. Understanding of the critical links between PSC and IBD are essential in designing clinical care pathways for these complex patients.
引用
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页码：1 / +
页数：15
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