Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates

被引：19

作者：

Zhou, Zhengwei ^{[1
]}

Cong, Mei ^{[2
]}

Li, Mengyao ^{[1
]}

Tintaru, Aura ^{[3
]}

Li, Jia ^{[4
]}

Yao, Jianhua ^{[4
]}

Xia, Yi ^{[1
]}

Peng, Ling ^{[2
]}

机构：

[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China

[2] Aix Marseille Univ, CNRS, Ctr Interdisciplinaire Nanosci Marseille, Equipe Labellisee Ligue Canc,UMR 7325, F-13288 Marseille, France

[3] Aix Marseille Univ, CNRS, Inst Chim Radicalaire, UMR 7273, Marseille, France

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 47期

基金：

中国国家自然科学基金;

关键词：

A(3) ADENOSINE RECEPTOR; EFFICIENT SIRNA DELIVERY; HEAT-SHOCK FACTOR-1; AMPHIPHILIC DENDRIMER; BIOMEDICAL APPLICATIONS; PAMAM DENDRIMER; DRUG-DELIVERY; IN-VIVO; NUCLEOSIDE; CANCER;

D O I：

10.1039/c8cc01221k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dendrimers possess intriguing "dendritic effects", which are unique characteristics that stem from the dendrimer generation and size. Here we report a "negative dendritic effect" observed during enzymatic hydrolysis of dendrimer conjugates. Such negative dendritic effects, though rarely reported, may be explored for tailored and generationdependent drug release.

引用

页码：5956 / 5959

页数：4

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