Does genetic variation in the insulin/insulin-like growth factor signaling pathway (IIS) underlie latitudinal life-history clines in North American Drosophila melanogaster? Durmaz et al. investigated how a clinally varying polymorphism in the IIS gene foxo affects fitness-related traits by isolating the effects of alternative low and high latitude alleles. The phenotypic effects of the polymorphism-for example, on body size-matched those normally observed across the cline, suggesting that variation in IIS is important for clinal life-history adaptation.
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Univ Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France
Leiden Univ, Inst Biol, Van der Klaauw Lab, Leiden, NetherlandsUniv Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France
Moiroux, Joffrey
Le Lann, Cecile
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机构:Univ Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France
Le Lann, Cecile
Seyahooei, Majeed A.
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Leiden Univ, Inst Biol, Van der Klaauw Lab, Leiden, NetherlandsUniv Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France
Seyahooei, Majeed A.
Vernon, Philippe
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Univ Rennes 1, ECOBIO, UMR 6553, Paimpoint, FranceUniv Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France
Vernon, Philippe
Pierre, Jean-Sebastien
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机构:Univ Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France
Pierre, Jean-Sebastien
Van Baaren, Joan
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Van Baaren, Joan
Van Alphen, Jacques J. M.
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Leiden Univ, Inst Biol, Van der Klaauw Lab, Leiden, NetherlandsUniv Rennes 1, CNRS, ECOBIO, UMR 6553, F-35042 Rennes, France