This study proposes a conceptual framework that intends to assess user satisfaction and the net benefits of implementing e-procurement system in government-owned hospitals. The study uses DeLone and McLean IS Success model as the underpinning theory to examine the relationship between three independent variables ( information quality, system quality and service quality) and the user satisfaction and net benefits of using an e-procurement system in government-owned hospitals. Predictably, the framework of this study is expected to provide a meaningful explanation on the degree of user satisfaction in using an e-procurement system in hospitals. Also, the study tries to provide a theoretical background to examine the benefits that are being derived from the system, especially regarding cost saving, timeliness, accountability and transparency. Finally, the paper suggested that empirical studies should be carried out to test the proposed model of this paper.