Palladium-Catalyzed Domino C,N-Coupling/Carbonylation/Suzuki Coupling Reaction: An Efficient Synthesis of 2-Aroyl-/Heteroaroylindoles

被引：102
|
作者：
Arthuis, Martin
Pontikis, Renee [1 ]
Florent, Jean-Claude
机构：
[1] Ctr Rech, Inst Curie, F-75248 Paris 05, France
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 20期
关键词：
CARBONYLATION REACTIONS; DERIVATIVES; CYCLIZATION; CASCADE; INDOLE; REAGENT; AGENTS;
D O I：
10.1021/ol901875z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient one-pot synthesis of 2-aroylindoles using a domino palladium-catalyzed C,N-coupling/carbonylation/C,C-coupling sequence Is described. The reaction involved easily prepared 2-gem-dibromovinylanilines and boronic acids under carbon monoxide. Optimized reaction conditions allowed the construction of a wide variety of highly functionalized 2-aroyl-/heteroaroylindoles in satisfactory yields.
引用
收藏
页码：4608 / 4611
页数：4
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