Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels

被引:83
|
作者
Villeneuve, Nicole F. [1 ]
Sun, Zheng [1 ]
Chen, Weimen [1 ]
Zhang, Donna D. [1 ]
机构
[1] Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
关键词
Nrf2; Keap1; p21; ROS; oxidative stress; ANTIOXIDANT RESPONSE; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; PROTECTION; ACTIVATION; LUNG;
D O I
10.4161/cc.8.20.9565
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:3255 / 3256
页数:2
相关论文
共 16 条
  • [1] MODIFICATION OF P16, P21 AND NRF2 EXPRESSION IN A MODEL OF UREMIC VASCULAR CALCIFICATION
    Laget, Jonas
    Hobson, Sam
    Jover, Bernard
    Muyor, Karen
    Duranton, Flore
    Kublickiene, Karolina
    Lajoix, Anne Dominique
    Stenvinkel, Peter
    Ciscart, Angel Argiles
    Gayrard, Nathalie
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2020, 35 : 157 - 157
  • [2] Allyl-isothiocyanate against colorectal cancer via the mutual dependent regulation of p21 and Nrf2
    Ren, Xiaoyan
    Zhang, Gaoshan
    Ling, Xiang
    Zhang, Linhua
    Tian, Yangyang
    Zhu, Guoxiang
    Wang, Pengbo
    Leavenworth, Jianmei W.
    Luo, Lin
    Li, Fengzhi
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2023, 957
  • [3] Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: Involvement of autophagy and p21/Nrf2 axis
    Nirmala Tilija Pun
    Pil-Hoon Park
    [J]. Scientific Reports, 7
  • [4] Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: Involvement of autophagy and p21/Nrf2 axis
    Pun, Nirmala Tilija
    Park, Pil-Hoon
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [5] Nrf2与p53/p21信号通路在肿瘤中作用的研究进展
    张高山
    蒋青青
    陈敏
    罗琳
    [J]. 实用药物与临床, 2023, 26 (06) : 549 - 555
  • [6] 1′-Acetoxychavicol Acetate Enhances the Phase II Enzyme Activities via the Increase in Intranuclear Nrf2 Level and Cytosolic p21 Level
    Yaku, Keisuke
    Matsui-Yuasa, Isao
    Azuma, Hideki
    Kojima-Yuasa, Akiko
    [J]. AMERICAN JOURNAL OF CHINESE MEDICINE, 2011, 39 (04): : 789 - 802
  • [7] A fine balance between life and death: modulation of BCL-2 family members by Toxoplasma gondii
    Arrizabalaga, Gustavo
    [J]. FRONTIERS IN MICROBIOLOGY, 2011, 2
  • [8] Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
    Chen, Weimin
    Sun, Zheng
    Wang, Xiao-Jun
    Jiang, Tao
    Huang, Zheping
    Fang, Deyu
    Zhang, Donna D.
    [J]. MOLECULAR CELL, 2009, 34 (06) : 663 - 673
  • [9] Inhibition of ferroptosis ameliorates hypertensive nephropathy through p53/Nrf2/p21 pathway by Taohongsiwu decoction: Based on network pharmacology and experimental validation
    Xie, Ting
    Bai, Zhenyu
    Chen, Zedong
    Liang, Huiyu
    Liu, Tianhao
    Lam, Lai Kwan
    Xu, Pengli
    Xie, Pengcheng
    Chen, Liguo
    Xiao, Ya
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2023, 312
  • [10] Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis
    Malhotra, Anshoo
    Nair, Praveen
    Dhawan, Devinder Kumar
    [J]. EUROPEAN JOURNAL OF CANCER PREVENTION, 2011, 20 (05) : 411 - 416