Early diagnosis of lung cancer: Impact of autofluorescence bronchoscopy

Introduction. - Less than 15% of all patients survive five years after a diagnosis of lung cancer. This poor prognosis is attributed to a lack of early detection. Among the methods of early diagnosis of bronchial cancer, autofluorescence bronchoscopy allows for the early identification of preinvasive bronchial lesions. The goat of this prospective study is to evaluate the contribution of the autofluorescence bronchoscopy, on a hospital site, over a period of one year. Methods. - All patients with an indication of autofluorescence bronchoscopy were included in the study. The following parameters were collected: age, sex, smoking status, FEV1, FVC, biopsy sites, histology, duration of examination. Results. - Two hundred and seventy-four patients were included. The average age was 63.8 years (+/- 12), the smoking status was 35packs/year (+/- 19). A fluorescence abnormality was detected in 131 patients and 165sites were biopsied. An histological abnormality was found in 76% of the samples, with 34hyperplasia (28%), 56squamous metaplasia (46%), three mild dysplasia (3%), two moderate dysplasia (2%), one severe dysplasia (1%), two carcinomas in situ (2%) and 21 invasive carcinomas (18%). Conclusion. - Autofluorescence bronchoscopy is an effective examination for the detection of the preinvasive neoplasic lesions and may be proposed when lung cancer is suspected. (C) 2009 Elsevier Masson SAS. All rights reserved.