Novel approaches for vaccine development

被引：173

作者：

Gebre, Makda S. ^{[1
,3
]}

Brito, Luis A. ^{[2
]}

Tostanoski, Lisa H. ^{[1
]}

Edwards, Darin K. ^{[2
]}

Carfi, Andrea ^{[2
,5
]}

Barouch, Dan H. ^{[1
,3
,4
,5
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Moderna Inc, Cambridge, MA 02139 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[5] Massachusetts Consortium Pathogen Readiness, Boston, MA 02115 USA

来源：

CELL | 2021年 / 184卷 / 06期

关键词：

MESSENGER-RNA VACCINES; DIRECT GENE-TRANSFER; IMMUNE-RESPONSES; IN-VIVO; PROTECTIVE EFFICACY; GOLD NANOPARTICLES; ANTIBODY-RESPONSES; ADENOVIRUS VECTOR; HIV-1; VACCINE; ANTIGEN;

D O I：

10.1016/j.cell.2021.02.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral pathogens, yet there are a number of examples where they have not been successful, such as for persistent infections, rapidly evolving pathogens with high sequence variability, complex viral antigens, and emerging pathogens. Novel technologies such as nucleic acid and viral vector vaccines offer the potential to revolutionize vaccine development as they are well-suited to address existing technology limitations. In this review, we discuss the current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges.

引用

页码：1589 / 1603

页数：15

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