Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research

被引:11
|
作者
Xu, Jie [1 ]
Zhang, Jifeng [1 ]
Yang, Dongshan [1 ]
Song, Jun [1 ]
Pallas, Brooke [2 ]
Zhang, Chen [3 ]
Hu, Jiafen [4 ]
Peng, Xuwen [5 ]
Christensen, Neil D. [4 ,6 ]
Han, Renzhi [3 ]
Chen, Y. Eugene [1 ]
机构
[1] Univ Michigan, Med Ctr, Sch Med, Ctr Adv Models Translat Sci & Therapeut, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Sch, Unit Lab Anim Med, Ann Arbor, MI USA
[3] Ohio State Univ, Dept Surg, Biomed Sci & Biophys Grad Program,Wexner Med Ctr, Dorothy M Davis Head & Lung Res Inst,Div Cardiac, Columbus, OH 43210 USA
[4] Penn State Canc Inst, Dept Pathol & Lab Med, Hershey, PA USA
[5] Penn State Univ, Dept Comparat Med, Coll Med, Hershey, PA USA
[6] Penn State Univ, Dept Microbiol & Immunol, Coll Med, Hershey, PA USA
基金
美国国家卫生研究院;
关键词
gene editing; Cas9; rabbit models; biomedical research; human diseases;
D O I
10.3389/fgene.2021.642444
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics.
引用
收藏
页数:12
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