Deep Brain Stimulation Effects on Gait Variability in Parkinson's Disease

被引:50
|
作者
Hausdorff, Jeffrey M. [1 ,2 ,3 ]
Gruendlinger, Leor [1 ]
Scollins, Lisa [4 ]
O'Herron, Siobhan [4 ]
Tarsy, Daniel [4 ]
机构
[1] Tel Aviv Sourasky Med Ctr, Lab Gait Anal & Neurodynam, Movement Disorders Unit, IL-64239 Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[4] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA
关键词
gait; deep brain stimulation; subthalamic nucleus; Parkinson's disease; gait variability; SUBTHALAMIC NUCLEUS STIMULATION; BALANCE PERFORMANCE; DUAL-TASKING; FALLS; IMPROVES; PEDUNCULOPONTINE; INITIATION; DISORDERS; ATTENTION; DYNAMICS;
D O I
10.1002/mds.22554
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on fall risk in patients with Parkinson's disease (PD.) currently remain unclear. Although several gait parameters, such as gait speed, have shown improvement with DBS, some studies have reported an increased fall risk following DBS. The purpose of this study was to examine the effect of bilateral DBS on gait variability, a marker of fall risk. The gait of 13 patients with idiopathic PD was analyzed to determine the influence of DBS, levodopa and both therapies together. Following treatment with both levodopa and STN DBS, subjects displayed improved gait speed, reduced gait variability (enhanced stability), and lower Unified Parkinson's Disease Rating Scale (UPDRS) scores. Although UPDRS scores improved with STN DBS alone, parallel improvements were not seen for gait variability. These findings suggest that different mechanisms may contribute to performance on UPDRS motor testing and gait stability in response to DBS. (C) 2009 Movement Disorder Society
引用
收藏
页码:1688 / 1692
页数:5
相关论文
共 50 条
  • [1] Effect of Subthalamic Deep Brain Stimulation on Variability of Gait Parameters in Parkinson's Disease
    Revilla, Fredy J.
    Larsh, Travis
    Duker, Andrew
    Bhattacharya, Amit
    [J]. NEUROLOGY, 2011, 76 (09) : A37 - A38
  • [2] Effect of subthalamic deep brain stimulation on variability of gait parameters in Parkinson's disease
    Larsh, T. R.
    Duker, A.
    Bhattacharya, A.
    Revilla, F. J.
    [J]. MOVEMENT DISORDERS, 2011, 26 : S74 - S74
  • [3] Clinical effects of deep brain stimulation on gait disorders in Parkinson's disease
    Wharen, R.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2010, 17 (05) : 639 - 640
  • [4] Rehabilitation on gait in Parkinson's disease with deep brain stimulation
    Volpe, D.
    [J]. MOVEMENT DISORDERS, 2008, 23 (01) : S205 - S205
  • [5] Deep brain stimulation and the effect on gait in Parkinson's disease
    Gilmore, G.
    Delrobaei, M.
    Tran, S.
    Ognjanovic, K.
    Jog, M.
    [J]. MOVEMENT DISORDERS, 2015, 30 : S88 - S88
  • [6] Deep Brain Stimulation and Levodopa Affect Gait Variability in Parkinson Disease Differently
    Su, Zi H.
    Patel, Salil
    Gavine, Bronwyn
    Buchanan, Tim
    Bogdanovic, Marko
    Sarangmat, Nagaraja
    Green, Alexander L.
    Bloem, Bastiaan R.
    FitzGerald, James J.
    Antoniades, Chrystalina A.
    [J]. NEUROMODULATION, 2023, 26 (02): : 382 - 393
  • [7] Effects of deep brain stimulation on gait and balance in Parkinson's disease: A quantitative assessment
    Shukla, A. Wagle
    McLeod, C.
    Defranco, M.
    Hass, C.
    Okun, M.
    [J]. MOVEMENT DISORDERS, 2013, 28 : S458 - S458
  • [8] Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson's Disease Patients
    Navratilova, Daniela
    Krobot, Alois
    Otruba, Pavel
    Nevrly, Martin
    Krahulik, David
    Kolar, Petr
    Kolarova, Barbora
    Kaiserova, Michaela
    Mensikova, Katerina
    Vastik, Miroslav
    Kurcova, Sandra
    Kanovsky, Petr
    [J]. FRONTIERS IN NEUROSCIENCE, 2020, 14
  • [9] Deep Brain Stimulation for Gait and Postural Symptoms in Parkinson's Disease
    Poetter-Nerger, Monika
    Volkmann, Jens
    [J]. MOVEMENT DISORDERS, 2013, 28 (11) : 1609 - 1615
  • [10] Troubleshooting Gait Disturbances in Parkinson's Disease With Deep Brain Stimulation
    Pozzi, Nicolo G.
    Palmisano, Chiara
    Reich, Martin M.
    Capetian, Philip
    Pacchetti, Claudio
    Volkmann, Jens
    Isaias, Ioannis U.
    [J]. FRONTIERS IN HUMAN NEUROSCIENCE, 2022, 16