Preparation and characterization of nanofunctionalized alginate/methacrylated gelatin hybrid hydrogels

被引：22
|
作者：
Kadri, R. [1 ]
Ben Messaoud, G. [1 ]
Tamayol, A. [2 ,3 ]
Aliakbarian, B. [4 ,5 ]
Zhang, H. Y. [6 ]
Hasan, M. [1 ]
Sanchez-Gonzalez, L. [1 ]
Arab-Tehrany, E. [1 ]
机构：
[1] Univ Lorraine, ENSAIA, Lab Ingn Biomol LIBio, Ave Foret de Haye,TSA 40602, F-54518 Vandoeuvre Les Nancy, France
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Biomat Innovat Res Ctr,Div Biomed Engn,Dept Med, Cambridge, MA 02139 USA
[3] MIT, Harvard Massachusetts Inst Technol, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[4] Univ Genoa, Dept Civil Chem & Environm Engn DICCA, Genoa, Italy
[5] Res Ctr Biol Inspired Engn Vasc Med & Longev BELO, Genoa, Italy
[6] Univ Lorraine, Inst Jean Lamour, Ecole Mines, CNRS,UMR 7198, Parc Saurupt,CS 14234, F-54042 Nancy, France
来源：
RSC ADVANCES | 2016年 / 6卷 / 33期
关键词：
PHYSICOCHEMICAL PROPERTIES; RHEOLOGICAL PROPERTIES; OXIDIZED ALGINATE; DRUG; NANOPARTICLES; FABRICATION; SCAFFOLDS; LIPOSOME; SYSTEMS; DESIGN;
D O I：
10.1039/c6ra03699f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Curcumin has been shown to be effective in many biomedical processes. However, the functionalization of hydrogel constructs with curcumin has been challenging due to its low water solubility. Here, we developed the preparation of alginate/methacrylated gelatin (GelMA) hybrid hydrogels functionalized with nanoliposomes encapsulating curcumin. Physicochemical properties of the polymer solutions and resulting hydrogels were studied. The engineered systems showed great rheological and swelling properties. The release behavior of curcumin-loaded nanoliposomes demonstrated their suitability as a drug delivery system. These novel biomaterial systems could be an excellent candidate for tissue engineering applications.
引用
收藏
页码：27879 / 27884
页数：6
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