Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy

被引：3

作者：

Hayashi, N.

Urashima, M.

Ikemoto, I.

Kuruma, H.

Arai, Y.

Kuwao, S.

Baba, S.

Egawa, S.

机构：

[1] Jikei Univ, Sch Med, Dept Urol, Minato Ku, Tokyo 1058461, Japan

[2] Jikei Univ, Sch Med, Div Clin Res & Dev, Minato Ku, Tokyo 1058461, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Urol, Aoba Ku, Sendai, Miyagi, Japan

[4] Higashi Yamato Hosp, Dept Pathol, Tokyo, Japan

[5] Kitasato Univ, Sch Med, Dept Urol, Sagamihara, Kanagawa 228, Japan

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2007年 / 10卷 / 01期

关键词：

prognosis; PSA; tumor volume; PSA tumor density;

D O I：

10.1038/sj.pcan.4500902

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to investigate the potential prognostic value of preoperative serum prostate-specific antigen levels adjusted for total tumor volume (PSA-TTV density) for outcome following radical prostatectomy for prostate cancer by retrospective review in 268 patients. Lower PSA-TTV density was not only associated with a significantly higher risk for biological failure (bF), systemic failure and cancer death but also an independent predictor for bF ( hazard ratio, 6.3). Therefore, these data suggest that there are subsets of prostate cancer with lower PSA secretion levels, and this phenotype is associated with a higher risk of failure after surgery.

引用

页码：60 / 65

页数：6

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[1] Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy
N Hayashi
M Urashima
I Ikemoto
H Kuruma
Y Arai
S Kuwao
S Baba
S Egawa
[J]. Prostate Cancer and Prostatic Diseases, 2007, 10 : 60 - 65
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