Antiplaque and antigingivitis efficacy of for updates cetylpyridinium chloride with zinc lactate compared with essential oil mouthrinses Randomized clinical trial

Background. The authors of this study aimed to evaluate the clinical antiplaque and antigingivitis effects of 3 oral hygiene regimens: toothbrushing with standard fluoride toothpaste and manual toothbrush and using a mouthrinse containing cetylpyridinium chloride, zinc lactate, and fluoride (CPC + Zn + F) in an alcohol-free base; toothbrushing with standard fluoride toothpaste and manual toothbrush and using a mouthrinse containing essential oils (EO) in an alcohol-free base; and toothbrushing with manual toothbrush and standard fluoride toothpaste and manual toothbrush (control). Methods. The participants (N = 120) were randomly assigned to study groups and followed the assigned regimens twice daily for 6 weeks. The participants were examined by a calibrated examiner for the Quigley-Hein plaque index (Turesky modification) and Loe-Silness gingival index at baseline, week 4, and week 6. Statistical analyses were performed separately for plaque and gingival indexes by means of analysis of variance, paired t test, and analysis of covariance (alpha = 0.05). Results. At week 4, the CPC + Zn + F group presented additional reductions in dental plaque compared with EO and control groups of (21.4% [ P < .001] and 31.4% [ P < .001], respectively). After 6 weeks, these values were 26.7% ( P < .001) and 44.8% ( P < .001), respectively. For Loe-Silness gingival index, additional reduction in the CPC + Zn + F group compared with EO were 10.6% ( P < .001) and 13.7% ( P < .001) at 4 and 6 weeks, respectively. Compared with control, these reductions were 13.6% ( P < .001) and 17.8% ( P < .001), respectively. Conclusions. The regimen including a mouthrinse containing CPC + Zn + F presented higher antiplaque and antigingivitis effects than EO and control regimens. Practical Implications. A mouthrinse containing CPC + Zn + F is an effective protocol for the control of dental plaque and gingivitis.