Analytical Evaluation of the Accuracy and Retention of Compounding Skills Among PharmD Students

Objective. To evaluate the accuracy and retention of compounding skills among students using analytical testing. Methods. Students compounded acetaminophen capsules from the same prescription at three time points (Exercise 1, 2, 3). The compounded products were analyzed (by HPLC) for acetaminophen content and the students' written reports were evaluated for accuracy of calculations and labeling. Results. During Exercise 1, 57.8% of the compounded capsule products were within the acceptable range, 92.2% during Exercise 2 and 75% during Exercise 3. The largest range in acetaminophen content was observed during Exercise 3 (76.08% to 135.2%) mainly due to calculation errors. Conclusion. While most students readily develop compounding skills during regular laboratory coursework, long-term competency depends on constant exposure to compounding activities and the retention of calculation skills.