(10E,12Z,15Z)-9-hydroxy-10,12,15-octadecatrienoic acid methyl ester as an anti-inflammatory compound from Ehretia dicksonii

被引：37
|
作者：
Dong, M
Oda, Y
Hirota, M
机构：
[1] Gifu Univ, United Grad Sch Agr Sci, Gifu 5011193, Japan
[2] Shinshu Univ, Fac Agr, Dept Biosci & Biotechnol, Nagano 3994598, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 04期
关键词：
anti-inflammatory; Ehretia dicksonii; TPA-induced edema; linolenic acid; linoleic acid;
D O I：
10.1271/bbb.64.882
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The methanol extract of Ehretia dicksonii provided (10E, 12Z, 15Z)-9-hydroxy-10, 12, 15-octadecatrienoic acid methyl ester (1) which was isolated as an anti-inflammatory compound. Compound 1 suppressed 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced inflammation on mouse ears at a dose of 500 mu g (the inhibitory effect (IE) was 43%). Linolenic acid methyl ester did not inhibit this inflammation at the same dose. However, the related compounds of 1, (9Z,11E)-13-hydroxy-9,11-octadecadienoic acid (5) and (9Z,11E)13-oxo-9,11-octadecadienoic acid (6), showed potent activity (IE500 mu g of 63% and 79%, respectively). Compounds 1, 4 ((9Z,12Z, 14E)-16-hydroxy-9, 12,14-octadecatrienoic acid), 5 and 6 also showed inhibitory activity toward soybean lipoxygenase at a concentration of 10 mu g / ml.
引用
收藏
页码：882 / 886
页数：5
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