Synthesis and properties of the oligonucleotide N3'->P5' phosphoramidates

被引：11
|
作者：
Gryaznov, SM
机构：
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期
关键词：
D O I：
10.1080/07328319708006106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Uniformly modified oligonucleotide N3'-->P5' phosphoramidates were synthesized. The prepared N3'-->P5' phosphoramidates form extremely stable duplexes and triplexes with complementary nucleic acids. Moreover, these compounds are highly resistant to enzymatic hydrolysis by snake venom phosphodiesterase and cellular nucleases and they show high antisense activity in vitro and in vivo.
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收藏
页码：899 / 905
页数：7
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