Programmable Paper-Based Microfluidic Devices for Biomarker Detections

被引：58
|
作者：
Soum, Veasna [1 ]
Park, Sooyong [1 ]
Brilian, Albertus Ivan [1 ]
Kwon, Oh-Sun [1 ]
Shin, Kwanwoo [1 ]
机构：
[1] Sogang Univ, Inst Biol Interfaces, Dept Chem, Seoul 04107, South Korea
来源：
MICROMACHINES | 2019年 / 10卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
paper-based microfluidic device; flow control; droplet actuation; multi-step assay; biomarker detection; digital microfluidic device; LATERAL FLOW IMMUNOASSAY; CAPILLARY-DRIVEN FLOW; LOW-COST; DIGITAL MICROFLUIDICS; COLORIMETRIC DETECTION; GOLD NANOPARTICLES; FLUID TRANSPORT; INSTRUMENT-FREE; FABRICATION; SENSITIVITY;
D O I：
10.3390/mi10080516
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.
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收藏
页数：25
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