Distribution of thyrotropin-releasing hormone immunoreactivity in the brain of larval and adult sea lampreys, Petromyzon marinus L.

This study investigated the distribution of thyrotropin-releasing hormone-immunoreactive (TRHir) neurons and fibers in the brain and retina of lampreys. Our results in the brains of large larvae and upstream-migrating adults of the sea lamprey showed the presence of TRHir neurons mainly in the preoptic region and the hypothalamus. A few TRHir neurons were also found in the striatum. The number and staining intensity of TRHir neurons increased from larval stages to adulthood, and the distribution of TRHir populations was wider in adults. The TRHir fibers were more easily traced in adults. Some TRHir fibers entered the neurohypophysis, although most fibers coursed in the different regions of the brain, mostly in the basal region, from the forebrain to the hindbrain. The presence of TRHir stellate cells was observed in the adenohypophysis. In the retina of adult lampreys, but not in that of larvae, TRHir amacrine cells are present.