Screening and surgical prophylaxis for hereditary cancer syndromes with high risk of endometrial and ovarian cancer

被引：10

作者：

Bercow, Alexandra S. ^{[1
,2
]}

Eisenhauer, Eric L. ^{[3
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Vincent Dept Obstet & Gynecol, Div Gynecol Oncol, Boston, MA 02115 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2019年 / 120卷 / 05期

关键词：

BRCA; endometrial cancer; hereditary cancer; Lynch syndrome; ovarian cancer; REDUCING SALPINGO-OOPHORECTOMY; BRCA2 MUTATION CARRIERS; NIPPLE-SPARING MASTECTOMY; LYNCH-SYNDROME; BREAST-CANCER; GYNECOLOGIC CANCER; FAMILY-HISTORY; WOMEN; SURGERY; SURVEILLANCE;

D O I：

10.1002/jso.25645

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the era of advanced cancer genomics, our recognition of hereditary cancer mutations continues to increase. Two of these conditions, which carry an increased risk of female cancers including endometrial, ovarian, breast, are hereditary breast and ovarian cancer syndrome and Lynch syndrome. Risk-reducing surgery, such as mastectomy, salpingo-oophorectomy, and hysterectomy may decrease cancer risk for mutation carriers. Background, indications, techniques, and consequences of these surgical procedures are reviewed.

引用

页码：864 / 872

页数：9

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