Metformin as an adjuvant in breast cancer treatment

被引：41

作者：

Roshan, Mohsin H. K. ^{[1
]}

Shing, Yan K. ^{[2
]}

Pace, Nikolai P. ^{[1
]}

机构：

[1] Univ Malta, Fac Med & Surg, Ctr Mol Med & Biobanking, MSD-2080 Msida, Malta

[2] Pamela Youde Nethersole Eastern Hosp, Hong Kong, Peoples R China

来源：

SAGE OPEN MEDICINE | 2019年 / 7卷

关键词：

Breast cancer; type; 2; diabetes; metformin; insulin; ACTIVATED PROTEIN-KINASE; ANTIDIABETIC DRUG METFORMIN; TRAIL RECEPTOR AGONISTS; CELL-PROLIFERATION; BINDING-PROTEIN; NEOPLASTIC TRANSFORMATION; ACQUIRED-RESISTANCE; INSULIN-RESISTANCE; PROSPECTIVE WINDOW; DIABETES-MELLITUS;

D O I：

10.1177/2050312119865114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Breast cancer is one of the most common malignancies in females. It is an etiologically complex disease driven by a multitude of cellular pathways. The proliferation and spread of breast cancer is intimately linked to cellular glucose metabolism, given that glucose is an essential cellular metabolic substrate and that insulin signalling has mitogenic effects. Growing interest has focused on anti-diabetic agents in the management of breast cancer. Epidemiologic studies show that metformin reduces cancer incidence and mortality among type 2 diabetic patients. Preclinical in vitro and in vivo research provides intriguing insight into the cellular mechanisms behind the oncostatic effects of metformin. This article aims to provide an overview of the mechanisms in which metformin may elicit its anti-cancerous effects and discuss its potential role as an adjuvant in the management of breast cancer.

引用

页数：16

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