Mean Platelet Volume and Related Factors in Patients at Different Stages of Diabetic Nephropathy: A Preliminary Study

被引：19
|
作者：
Turgutalp, Kenan [1 ]
Ozhan, Onur [2 ]
Akbay, Esen [2 ]
Tombak, Anil [3 ]
Tiftik, Naci [3 ]
Ozcan, Turkay [4 ]
Yilmaz, Sercan [1 ]
Helvaci, Ilter [5 ]
Kiykim, Ahmet [1 ]
机构：
[1] Mersin Univ, Sch Med, Dept Internal Med, Div Nephrol, TR-33079 Mersin, Turkey
[2] Mersin Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, TR-33079 Mersin, Turkey
[3] Mersin Univ, Sch Med, Dept Internal Med, Div Hematol, TR-33079 Mersin, Turkey
[4] Mersin Univ, Sch Med, Dept Cardiol, TR-33079 Mersin, Turkey
[5] Mersin Univ, Silifke Sch Appl Technol & Management, Dept Business Informat Management, TR-33079 Mersin, Turkey
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2014年 / 20卷 / 02期
关键词：
mean platelet volume; diabetes mellitus; proteinuria; diabetic nephropathy; renal failure; cardiovascular disease; ACUTE ISCHEMIC-STROKE; NEPHROTIC SYNDROME; DISEASE; MELLITUS; ATHEROSCLEROSIS; CLASSIFICATION; HYPERTENSION; PROGRESSION; INDEXES; GLUCOSE;
D O I：
10.1177/1076029612456734
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Mean platelet volume (MPV) is an independent cardiovascular disease predictor, and characteristics of MPV in patients with diabetic nephropathy (DN) are not well known. Aim: To determine the MPV levels in patients at different stages of DN. Patients and Methods: The MPV levels were investigated in healthy participants (group 1, n = 157), patients with type 2 diabetes mellitus without complication (group 2, n = 160), diabetic patients with clinical proteinuria (group 3, n = 144), and in patients with chronic kidney disease due to DN (group 4, n = 160). Findings: The MPV level was higher in all diabetic patients than that in normal participants (P < .05). The MPV values had a positive correlation with the serum creatinine and proteinuria, and a negative correlation with the glomerular filtration rate ([GFR] P < .001 for all, r values; .72, and .82, and -.92, respectively). Conclusion: The MPV values were higher in diabetic groups than that in normal participants. Both GFR and proteinuria were the most powerful determinants of MPV.
引用
收藏
页码：190 / 195
页数：6
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