Effects of early loss of permanent first molars on the development of third molars

Introduction: The aim of this study was to evaluate whether early loss of the permanent first molars has an effect on the developmental stages and eruptive conditions of the third molars. Methods: Panoramic radiographs and dental casts of 165 adolescent patients (103 boys, 62 girls) with unilateral early loss of a permanent first molar were used to assess the developmental stages of the third molars. The formation stages of third molars on the extraction sides were evaluated, and the formative conditions of the contralateral teeth were used as controls. The Mann-Whitney U test was used to assess sex differences in formation stages of the third molars. The Kruskal-Wallis analysis of variance (ANOVA) was used to determine whether there were significant differences in the developmental stages of the third molars between the various extraction quadrants. In addition, the Wilcoxon signed rank test and the paired t test were used to compare the differences in the developmental stages and eruptive conditions of the third molars between the extraction and control sides. Results: The Mann-Whitney U test showed no significant sex differences for the formation stage of the third molars. Therefore, the data from both sexes were pooled. No statistically significant differences were found in the developmental stages of the third molars between the various extraction quadrants in the same jaw and between those in the mandible and maxilla. However, statistically significant differences were found in developmental stages (P < .001) and eruptive conditions (P < .05) of the third molars between the extraction and control sides. The development of the third molars on the extraction side was significantly accelerated compared with the contralateral teeth. Conclusions: Early loss of the permanent first molars might have an accelerating effect on the development of the third molar on the extraction side compared with the contralateral teeth. Therefore, emergence of the third molars on the extraction side might be hastened, and these teeth might erupt earlier than the contralateral teeth.