Asymmetric Copper-Catalyzed Propargylic Substitution Reaction of Propargylic Acetates with Enamines

被引：71

作者：

Fang, Ping ^{[1
]}

Hou, Xue-Long ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

基金：

中国国家自然科学基金;

关键词：

ALLYLIC ALKYLATIONS; LIGANDS; COMPLEXES; ALCOHOLS;

D O I：

10.1021/ol901891u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enamines served as carbon-nucleophiles for the first time in the Cu-catalyzed asymmetric propargylic substitution reaction of propargylic acetates, providing corresponding chiral beta-ethynyl-substituted ketones in high yields and in good to high enantioselectivity.

引用

页码：4612 / 4615

页数：4

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