Alcohol use disorder: A pre-existing condition for COVID-19?

被引：39
|
作者：
Bailey, Kristina L. [1 ,2 ]
Samuelson, Derrick R. [2 ]
Wyatt, Todd A. [1 ,2 ,3 ]
机构：
[1] Dept Vet Affairs Omaha Western Iowa Hlth Care Sys, Res Serv, Omaha, NE 68105 USA
[2] Univ Nebraska Med Ctr, Dept Internal Med, Pulm Crit Care & Sleep, Omaha, NE 68198 USA
[3] Univ Nebraska Med Ctr, Dept Environm Agr & Occupat Hlth, Omaha, NE 68198 USA
来源：
ALCOHOL | 2021年 / 90卷
基金：
美国国家卫生研究院;
关键词：
alcohol; coronavirus; COVID-19; injury; lung; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; ALVEOLAR MACROPHAGE; PROTEIN ADDUCTS; LUNG INJURY; SEVERITY; ETHANOL; ABUSE; IMMUNODEFICIENCY; MALONDIALDEHYDE; INFECTIONS;
D O I：
10.1016/j.alcohol.2020.10.003
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Alcohol misuse is long established as a contributor to the pathophysiology of the lung. The intersection of multi-organ responses to alcohol-mediated tissue injury likely contributes to the modulation of lung in response to injury. Indeed, the negative impact of alcohol on susceptibility to infection and on lung barrier function is now well documented. Thus, the alcohol lung represents a very likely comorbidity for the negative consequences of both COVID-19 susceptibility and severity. In this review, we present the known alcohol misuse ramifications on the lung in the context of the current coronavirus pandemic. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：11 / 17
页数：7
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