Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

被引：115

作者：

Yarchoan, Mark ^{[1
]}

Agarwal, Parul ^{[2
]}

Villanueva, Augusto ^{[3
]}

Rao, Shuyun ^{[4
]}

Dawson, Laura A. ^{[5
]}

Llovet, Josep M. ^{[6
,7
,8
]}

Finn, Richard S. ^{[9
]}

Groopman, John D. ^{[10
]}

El-Serag, Hashem B. ^{[11
]}

Monga, Satdarshan P. ^{[12
,13
,14
]}

Wang, Xin Wei ^{[15
]}

Karin, Michael ^{[16
]}

Schwartz, Robert E. ^{[17
]}

Tanabe, Kenneth K. ^{[18
]}

Roberts, Lewis R. ^{[19
]}

Gunaratne, Preethi H. ^{[20
]}

Tsung, Allan ^{[21
]}

Brown, Kimberly A. ^{[22
]}

Lawrence, Theodore S. ^{[23
]}

Salem, Riad ^{[24
]}

Singal, Amit G. ^{[25
]}

Kim, Amy K. ^{[26
]}

Rabiee, Atoosa ^{[27
]}

Resar, Linda ^{[26
]}

Hoshida, Yujin ^{[25
]}

He, Aiwu Ruth ^{[28
]}

Ghoshal, Kalpana ^{[29
]}

Ryan, Patrick B. ^{[30
]}

Jaffee, Elizabeth M. ^{[1
]}

Guha, Chandan ^{[31
]}

Mishra, Lopa ^{[4
,27
]}

Coleman, C. Norman ^{[32
]}

Ahmed, Mansoor M. ^{[33
]}

机构：

[1] Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Dept Oncol Gastrointestinal Canc, Baltimore, MD USA

[2] Univ Penn, Dept Internal Med, Philadelphia, PA 19104 USA

[3] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

[4] George Washington Univ, Dept Surg, Ctr Translat Med, Washington, DC USA

[5] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada

[6] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Liver Dis, Mt Sinai Liver Canc Program, New York, NY 10029 USA

[7] Univ Barcelona, Hosp Clin, Translat Res Hepat Oncol, Liver Unit,IDIBAPS,CIBERehd, Catalonia, Spain

[8] ICREA, Barcelona, Catalonia, Spain

[9] UCLA, Geffen Sch Med, Dept Med, Div Hematol Oncol, Santa Monica, CA USA

[10] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth & Engn, Baltimore, MD USA

[11] Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA

[12] Univ Pittsburgh, Dept Pathol & Med, Pittsburgh, PA USA

[13] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Pittsburgh, PA USA

[14] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[15] NCI, Dept Human Carcinogenesis, Bethesda, MD 20892 USA

[16] Univ Calif San Diego, Sch Med, Dept Pharmacol, San Diego, CA 92103 USA

[17] Cornell Univ, Sanford I Weill Med Coll, Dept Gastroenterol & Hepatol, New York, NY 10021 USA

[18] Massachusetts Gen Hosp, Dept Surg Oncol, Boston, MA 02114 USA

[19] Mayo Clin, Dept Med, Rochester, MN USA

[20] Univ Houston, Dept Biol & Biochem, Houston, TX USA

[21] Ohio State Univ, Dept Surg, Wexner Med Ctr, Columbus, OH 43210 USA

[22] Henry Ford Hosp, Dept Gastroenterol & Hepatol, Detroit, MI 48202 USA

[23] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[24] Feinberg Sch Med, Dept Radiol, Chicago, IL USA

[25] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Digest & Liver Dis, Dallas, TX USA

[26] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[27] VA Med Ctr, Dept Gastroenterol & Hepatol, Washington, DC USA

[28] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Med & Oncol, Washington, DC USA

[29] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA

[30] Janssen Res & Dev LLC, Titusville, NJ USA

[31] Albert Einstein Coll Med, Dept Radiat Oncol Pathol & Urol, Bronx, NY 10467 USA

[32] NCI, Div Canc Treatment & Diag, Radiat Res Program, Rockville, MD USA

[33] NCI, Div Canc Treatment & Diag, Mol Radiat Therapeut, Radiat Res Program, Rockville, MD USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 17期

关键词：

DOUBLE-BLIND; SORAFENIB; PHASE-3; PLACEBO;

D O I：

10.1158/0008-5472.CAN-19-0803

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally. The landscape of systemic therapy has recently changed, with six additional systemic agents either approved or awaiting approval for advanced stage HCC. While these agents have the potential to improve outcomes, a survival increase of 2-5 months remains poor and falls short of what has been achieved in many other solid tumor types. The roles of genomics, underlying cirrhosis, and optimal use of treatment strategies that include radiation, liver transplantation, and surgery remain unanswered. Here, we discuss new treatment opportunities, controversies, and future directions in managing HCC. © 2019 American Association for Cancer Research.

引用

页码：4326 / 4330

页数：5

共 50 条

[1] Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma (vol 79, pg 4326, 2019)
Yarchoan, Mark
Agarwal, Parul
Villanueva, Augusto
Rao, Shuyun
Dawson, Laura
Karasic, Thomas
Llovet, Joseph
Finn, Richard
Groopman, John
El-Serag, Hashem
Monga, Satdarshan
Wang, Xin Wei
Karin, Michael
Schwartz, Robert
Tanabe, Kenneth
Roberts, Lewis
Gunaratne, Preethi
Tsung, Allan
Brown, Kimberly
Lawrence, Theodore
Salem, Riad
Singal, Amit
Kim, Amy
Rabiee, Atoosa
Resar, Linda
Meyer, Jeffrey
Hoshida, Yujin
He, Aiwu Ruth
Ghoshal, Kalpana
Ryan, Patrick
Jaffee, Elizabeth
Guha, Chandan
Mishra, Lopa
Coleman, Norman
Ahmed, Mansoor
[J]. CANCER RESEARCH, 2019, 79 (22) : 5897 - 5897
[2] Recent Findings on Nanotechnology-based Therapeutic Strategies Against Hepatocellular Carcinoma
Samie, Hany A. Abdel
Saeed, Mohd
Faisal, Syed Mohd
Kausar, Mohd Adnan
Kamal, Mohammad A.
[J]. CURRENT DRUG METABOLISM, 2019, 20 (04) : 283 - 291
[3] Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma
Bouattour, Mohamed
Raymond, Eric
Qin, Shukui
Cheng, Ann-Lii
Stammberger, Uz
Locatelli, Giuseppe
Faivre, Sandrine
[J]. HEPATOLOGY, 2018, 67 (03) : 1132 - 1149
[4] Recent developments with immunotherapy for hepatocellular carcinoma
Waidmann, Oliver
[J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2018, 18 (08) : 905 - 910
[5] Recent developments in radiotherapy for hepatocellular carcinoma
Park, Hee Chul
[J]. JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, 2013, 56 (11): : 983 - 992
[6] Engineering principles for rationally design therapeutic strategies against hepatocellular carcinoma
Hernandez-Magana, Alexis
Bensussen, Antonio
Martinez-Garcia, Juan Carlos
Alvarez-Buylla, Elena R.
[J]. FRONTIERS IN MOLECULAR BIOSCIENCES, 2024, 11
[7] Targeting BMP2 for therapeutic strategies against hepatocellular carcinoma
Li, Ping
Shang, You
Yuan, Liying
Tong, Jialing
Chen, Quan
[J]. TRANSLATIONAL ONCOLOGY, 2024, 46
[8] Recent advances in hepatocellular carcinoma therapeutic strategies and imaging-guided treatment
Du, Yan
Liu, Di
Du, Yongzhong
[J]. JOURNAL OF DRUG TARGETING, 2022, 30 (03) : 287 - 301
[9] Immunotherapeutic strategies against hepatocellular carcinoma
Geissler, M
Mohr, L
Blum, HE
[J]. MALIGNANT LIVER TUMOURS: BASIC CONCEPTS AND CLINICAL MANAGEMENT, 2003, 127 : 111 - 123
[10] Current Therapeutic Strategies for Hepatocellular Carcinoma in Japan
Kudo, Masatoshi
[J]. LIVER CANCER, 2023, 12 (06) : 497 - 509

← 1 2 3 4 5 →